Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, et al.
#SYSTEM SHOCK 2 BACKGROUND TRIAL#
Definitions, mechanisms, relevant outcomes, and clinical trial coordination. The American-European Consensus Conference on ARDS. 31(4):1250-6.īernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, et al.
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference.
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al.
101(6):1644-55.Īmerican College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. American College of Chest Physicians/Society of Critical Care Medicine. The ACCP/SCCM Consensus Conference Committee. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, et al. Epidemiology of sepsis syndrome in 8 academic medical centers. Sands KE, Bates DW, Lanken PN, Graman PS, Hibberd PL, Kahn KL, et al. A multicenter prospective study in intensive care units. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJ, Baron EJ, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Source: Dellinger RP, Levy MM, Rhodes A, et al, for the Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Hyperlactatemia: Above upper limits of laboratory normalĪPTT = activated partial thromboplastin time FIO 2 = fraction of inspired oxygen INR = international normalized ratio MAP = mean arterial pressure PaO 2 = partial pressure of oxygen PEEP = positive end-expiratory pressure PT = prothrombin time SBP = systolic blood pressure. Hyperbilirubinemia: Plasma total bilirubin >2 mg/dL or 34.2 µmol/LĬreatinine increase >0.5 mg/dL or 44.2 µmol/LĪcute oliguria: Urine output 2 mg/dL or 176.8 µmol/LĪcute oliguria: Urine output 1.5, aPTT >60 s, or platelets 1.5 or platelets 1 mmol/L decreased capillary refill or mottling The specific clinical features depend on where the patient falls on that continuum.Īrterial hypoxemia: PaO 2/FIO 24 mg/dL or 70 µmol/L Signs and symptomsĭetrimental host responses to infection occupy a continuum that ranges from sepsis to septic shock and multiple organ dysfunction syndrome (MODS). What was previously called severe sepsis is now the new definition of sepsis. This new 2016 definition, also called Sepsis-3, eliminates the requirement for the presence of systemic inflammatory response syndrome (SIRS) to define sepsis, and it removed the severe sepsis definition. Septic shock is defined by persisting hypotension requiring vasopressors to maintain a mean arterial pressure of 65 mm Hg or higher and a serum lactate level greater than 2 mmol/L (18 mg/dL) despite adequate volume resuscitation. Septic shock occurs in a subset of patients with sepsis and comprises of an underlying circulatory and cellular/metabolic abnormality that is associated with increased mortality. Sepsis is defined as life-threatening organ dysfunction due to dysregulated host response to infection, and organ dysfunction is defined as an acute change in total Sequential Organ Failure Assessment (SOFA) score of 2 points or greater secondary to the infection cause. Management of Acute Respiratory Distress Syndrome.Inotropic Therapy and Augmented Oxygen Delivery.General Treatment Guidelines in Septic Shock.
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